Biotransformation of artemisinin by Aspergillus niger
| Autor: | Pingying Wei, Yulian Zhan, Zhencheng Chen, Yunshan Wu, John S. Williamson, Hua Liu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
biology
Chemistry Stereochemistry Aspergillus niger Temperature General Medicine Hydrogen-Ion Concentration biology.organism_classification Applied Microbiology and Biotechnology Peroxide Artemisinins chemistry.chemical_compound Biotransformation medicine Artemisinin G Organic chemistry Artemisinin Biotechnology medicine.drug |
| Zdroj: | Applied Microbiology and Biotechnology. 99:3443-3446 |
| ISSN: | 1432-0614 0175-7598 |
| DOI: | 10.1007/s00253-015-6464-x |
| Popis: | Biotransformation of artemisinin (1) by Aspergillus niger was investigated. During 12 days at 28 °C and pH 6.0, A. niger transformed artemisinin into four products. They were identified as 3β-hydroxy-4,12-epoxy-1-deoxyartemisinin (2), artemisinin G (3), 3,13-epoxyartemisinin (4), and 4α-hydroxy-1-deoxyartemisinin (5). Products 2 and 4 are new compounds and are being reported here for the first time. The product 4 contains a 3,13-epoxy structure. This is the first report of epoxidation of artemisinin using microbial strains. The product 4 still has an intact peroxide bridge and therefore can be used as a scaffold for further structural modification using chemical and biological methods in the search for new antimalarial drugs. |
| Databáze: | OpenAIRE |
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