Evaluation of Ductal Tissue in Coarctation of the Aorta Using X-Ray Phase-Contrast Tomography
| Autor: | Toru Akaike, Yukihiro Kaneko, Susumu Minamisawa, Gen Shinohara, Hironori Matsuhisa, Ryuma Iwaki, Kiyozo Morita, Masashi Takahashi, Takuro Tsukube, Masato Hoshino, Naoto Yagi, Syuichi Yoshitake, Yoshihiro Oshima |
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| Rok vydání: | 2021 |
| Předmět: |
Coarctation of the aorta
Aorta Thoracic 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Aortic Coarctation 03 medical and health sciences Imaging Three-Dimensional 0302 clinical medicine Ductus arteriosus medicine.artery medicine Humans Thoracic aorta business.industry X-Rays Ductus Arteriosus Anatomy medicine.disease Staining medicine.anatomical_structure Transcription Factor AP-2 030228 respiratory system Descending aorta Pediatrics Perinatology and Child Health Tomography Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Immunostaining Elastic fiber |
| Zdroj: | Pediatric Cardiology. 42:654-661 |
| ISSN: | 1432-1971 0172-0643 |
| DOI: | 10.1007/s00246-020-02526-5 |
| Popis: | We assessed the histological accuracy of X-ray phase-contrast tomography (XPCT) and investigated three-dimensional (3D) ductal tissue distribution in coarctation of the aorta (CoA) specimens. We used nine CoA samples, including the aortic isthmus, ductus arteriosus (DA), and their confluences. 3D images were obtained using XPCT. After scanning, the samples were histologically evaluated using elastica van Gieson (EVG) staining and transcription factor AP-2 beta (TFAP2B) immunostaining. XPCT sectional images clearly depicted ductal tissue distribution as low-density areas. In comparison with EVG staining, the mass density of the aortic wall positively correlated with elastic fiber formation (R = 0.69, P |
| Databáze: | OpenAIRE |
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