THE EFFECTS OF TOXOPLASMA GONDII INFECTIONS ON ANXIETY, DEPRESSION AND LEARNING IN OFFSPRINGS OF INFECTED PARENTS
| Autor: | Kerem Yaman, Ayhan Cetinkaya, Enes Eğilmez, Mücahit Çakmak, Hayriye Orallar, Bihter Bozat Gökçe, Erol Ayaz |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Volume: 14, Issue: 1 33-45 Medical Sciences |
| ISSN: | 1308-7312 |
| Popis: | Toxoplasma Gondii isa zoonotic parasite showing intracellular localization. Although it doesn’tselect a specific region in the brain tissue, the cyst forms occurring in thechronic phase may cause behavioral changes when it is located in the brainregions related to behavior. The aim of this study is to investigate whetherthere is a relationship between neurodegenerative and neuropsychiatric diseasescaused by antibodies transmitted to the first generation of T.Gondii infectionby behavioral tests. In this study, using a total of 24 female and 6 male rats.Behavioral tests have been applied to F1 generation groups female and male. Inthis study, female rats with chronic T.Gondii infection have been found to haveincreased anxiety in open field in the first generation male offsprings anddecreased locomotor activity. Increased mobility in male offsprings has beenobserved in the elevated plus maze test. In female offspring, it has reducedanxiety and depression. Toxoplasma Gondii is a zoonotic parasite showing intracellular localization. Although it doesn’t select a specific region in the brain tissue, the cyst forms occurring in the chronic phase may cause behavioral changes when it is located in the brain regions related to behavior. The aim of this study is to investigate whether there is a relationship between neurodegenerative and neuropsychiatric diseases caused by antibodies transmitted to the first generation of T.Gondii infection by behavioral tests. In this study, using a total of 24 female and 6 male rats. Behavioral tests have been applied to F1 generation groups female and male. In this study, female rats with chronic T.Gondii infection have been found to have increased anxiety in open field in the first generation male offsprings and decreased locomotor activity. Increased mobility in male offsprings has been observed in the elevated plus maze test. In female offspring, it has reduced anxiety and depression |
| Databáze: | OpenAIRE |
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