Treatment and prevention of inflammatory responses and oxidative stress in patients with obstructive sleep apnea hypopnea syndrome using Chinese herbal medicines
| Autor: | Lin Ye, Qin Chen, Qichang Lin, Xuchu Hong, Rong Jing Lin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cancer Research
medicine.medical_specialty Polysomnography medicine.disease_cause Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Oral administration Internal medicine medicine medicine.diagnostic_test business.industry Epworth Sleepiness Scale Therapeutic effect Articles General Medicine medicine.disease Malondialdehyde Obstructive sleep apnea chemistry 030220 oncology & carcinogenesis Immunology business Hypopnea 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Experimental and Therapeutic Medicine. 12:1572-1578 |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2016.3484 |
| Popis: | The present study aimed to investigate the therapeutic effects of Chinese herbal medicines for the treatment and prevention of inflammatory responses and oxidative stress in obstructive sleep apnea hypopnea syndrome (OSAHS). A total of 60 patients with OSAHS were randomly divided into two groups (n=30/group): The experimental group, who received the conventional treatment + oral administration of the traditional Chinese herbal formula, Jiawei Di Tan Tang; and the control group, who received the conventional treatment only. OSAHS patients were included in the current study if they presented with snoring and had an apnea-hypopnea index (AHI) of >30 in a polysomnography study, without comorbidities. The therapeutic course lasted 12 weeks in both groups. Alterations to the mean clinical symptom score, Epworth sleepiness scale (ESS) and AHI scores, lowest nocturnal blood oxygen saturation (SaO2) and the serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin (IL)-6, tumor necrosis factor (TNF)-α and C-reactive protein (CRP) prior to and following treatment were observed. The mean clinical symptom score was significantly decreased in the experimental group post-treatment compared with the control group (P |
| Databáze: | OpenAIRE |
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