Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy
| Autor: | Noémie Vulquin, Cédric Chevalier, Gilles Truc, Cédric Desandes, Aurélie Bertaut, Philippe Maingon, Gilles Créhange, Magali Quivrin, Mireille Folia, Christian Duvillard |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Waiting time
Larynx medicine.medical_specialty medicine.medical_treatment Loco-regional failure Head and neck squamous-cell carcinoma R895-920 Intensity modulated radiation therapy Article 030218 nuclear medicine & medical imaging 03 medical and health sciences Medical physics. Medical radiology. Nuclear medicine 0302 clinical medicine Carcinoma otorhinolaryngologic diseases Medicine Radiology Nuclear Medicine and imaging RC254-282 Chemotherapy Upstaging business.industry Pharynx Neoplasms. Tumors. Oncology. Including cancer and carcinogens Retrospective cohort study medicine.disease Quality assurance Surgery Radiation therapy stomatognathic diseases medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis business |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 1, Iss C, Pp 27-32 (2016) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Background and purpose To evaluate the influence of delays for radiotherapy on survival, recurrence and upstaging for head and neck squamous-cell carcinoma (HNSCC) with no nodal involvement treated with intensity modulated radiotherapy (IMRT). Material and methods This retrospective study included 63 consecutive patients with HNSCC located in the pharynx and larynx and treated with exclusive IMRT with or without chemotherapy. Survival, loco-regional or distant failure and upstaging were analyzed according to the waiting time. Results Mean waiting time for treatment was 62.5days for the hypopharynx subgroup (range=37–102), 63days for the larynx subgroup (range=19–128) and 58.5days for the oropharynx subgroup (range=29–99) ( p =0.725). Nine patients (14%) experienced upstaging. Loco-regional or distant failure occurred in 18 patients. Beyond a delay of 50days, 19% of patients had local failure, 17% nodal recurrence and 11% distant failure. Within a delay of 50days, no nodal or distant failure was observed and only 1 patient experienced local recurrence. Upstaging and overall survival were not significantly affected by an increased waiting time. Conclusion For N0 patients treated with IMRT for HNSCC, waiting time around 50days after the diagnosis was not significantly associated with an excessive risk of upstaging or recurrence. |
| Databáze: | OpenAIRE |
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