Sensory gating and inhibitory function in late-life schizophrenia
| Autor: | David L. Braff, Harris Mj, McDowd Jm, Diane L. Filion |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Senescence
Male medicine.medical_specialty Psychosis Reflex Startle Audiology behavioral disciplines and activities Latent inhibition Reference Values mental disorders medicine Reaction Time Humans Attention Habituation Psychiatry Habituation Psychophysiologic Prepulse inhibition Aged Psychiatric Status Rating Scales Sensory gating Cognitive disorder Middle Aged medicine.disease Psychiatry and Mental health Inhibition Psychological medicine.anatomical_structure Acoustic Stimulation Chronic Disease Negative priming Schizophrenia Female Schizophrenic Psychology Psychology Arousal Follow-Up Studies |
| Zdroj: | Schizophrenia bulletin. 19(4) |
| ISSN: | 0586-7614 |
| Popis: | Although similarities between the cognitive deficits observed in schizophrenia and those observed in aging have been recognized for over 50 years, little work has been done to directly examine these similarities or their implications for late-life schizophrenia. We review studies of prepulse inhibition, habituation, latent inhibition, and negative priming that indicate marked similarities in the patterns of deficits observed in schizophrenia and in aging. We also present new data from preliminary studies of prepulse inhibition and negative priming in which we compared young normal controls, older adult normal controls, and late-life schizophrenia patients. For both measures, both schizophrenia patients and older adults showed an inhibitory deficit relative to young controls. In the case of negative priming, older schizophrenia patients showed evidence of greater inhibitory dysfunction than did normal older adults, suggesting that older schizophrenia patients suffer a deficit resulting from the combined effects of schizophrenia and aging. The implications of these results and directions for future research are discussed. |
| Databáze: | OpenAIRE |
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