A Retrospective Study of Definitive Chemoradiotherapy for Elderly Patients With Esophageal Cancer
| Autor: | Satoshi Takeuchi, Makoto Tahara, Keiko Minashi, Keiji Nihei, Atsushi Ohtsu, Tomonori Yano, Manabu Muto, Toshihiko Doi, Takashi Kojima, Kiyomi Mera |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Esophageal Neoplasms genetic structures Comorbidity Radiation Dosage Japan Cause of Death Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Combined Modality Therapy Stage (cooking) Survival rate Aged Neoplasm Staging Retrospective Studies Cause of death business.industry Retrospective cohort study social sciences Definitive chemoradiotherapy Esophageal cancer medicine.disease Hematologic Diseases humanities Surgery Survival Rate Patient Compliance Female Fluorouracil Cisplatin Neoplasm Recurrence Local business |
| Zdroj: | American Journal of Clinical Oncology. 30:607-611 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/coc.0b013e3180ca7c84 |
| Popis: | The efficacy and safety of definitive chemoradiotherapy (CRT) for elderly patients with esophageal cancer have not been fully elucidated yet. We conducted a retrospective comparison of the outcomes of CRT between elderly and nonelderly patients with Stage II-III (non-T4) esophageal cancer.There were 33 elderly (aged over 71) patients and 145 nonelderly (aged under 70) patients who fulfilled the selection criteria. The treatment consisted of the continuous infusion of fluorouracil (5-FU) and the intravenous infusion of cisplatin (CDDP) combined with 60 Gy of radiation.Although the CR rate was almost identical between the 2 groups (63.6% vs. 63.4%, respectively), the recurrence rate after CR was higher in the elderly patients group than in the nonelderly patients group (47.6% vs. 33.7%, P = 0.32). The elderly patient group showed a significantly inferior survival in comparison to the nonelderly patient group with a median survival time (14.7 months vs. 35.1 months, P = 0.01). Discontinuations at the end of CRT were more frequent in the elderly patient group than in the nonelderly patients (57.6% vs. 17.3%, P = 0.01). In addition, over Grade 3 hematologic adverse events were more frequently observed in elderly patients than in nonelderly patients. There were no obvious differences in patients who died of causes other than primary disease.This retrospective analysis revealed a significantly inferior efficacy even in selected elderly patients. Although improving the dose intensity of CRT should be desirable even in elderly patients, it seems to be difficult because of more substantial toxicity in elderly patients. |
| Databáze: | OpenAIRE |
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