Fertility preservation in BRCA-mutated women: when and how?
| Autor: | J. Raad, Isabelle Cedrin-Durnerin, Marjorie Comtet, Michael Grynberg, Charlotte Sonigo, C. Vinolas |
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| Přispěvatelé: | Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
HEREDITARY BREAST
Cancer Research endocrine system diseases [SDV]Life Sciences [q-bio] Genes BRCA2 Genes BRCA1 Gene mutation Bioinformatics 0302 clinical medicine FEMALE FERTILITY Fertility preservation Ovarian Reserve skin and connective tissue diseases media_common AMERICAN-SOCIETY Ovarian Neoplasms education.field_of_study 030219 obstetrics & reproductive medicine Fertility Preservation General Medicine female genital diseases and pregnancy complications 3. Good health Oncology 030220 oncology & carcinogenesis Female BREAST-CANCER PATIENTS Risk Genotype PREIMPLANTATION GENETIC DIAGNOSIS media_common.quotation_subject ADJUVANT TAMOXIFEN Population Breast Neoplasms Fertility OVARIAN-CANCER 03 medical and health sciences Ovulation Induction medicine Humans Genetic Testing education Ovarian reserve Preimplantation Diagnosis Cryopreservation Pregnancy INTERNATIONAL CONSENSUS GUIDELINES business.industry BRCA mutation PREMATURE MENOPAUSE Cancer medicine.disease Mutation business IN-VITRO FERTILIZATION |
| Zdroj: | Future Oncology Future Oncology, Future Medicine, 2018, 14 (5), ⟨10.2217/fon-2017-0415⟩ |
| ISSN: | 1479-6694 1744-8301 |
| Popis: | International audience; BRCA 1 and 2 genes play a critical role in the safeguarding of DNA integrity. It is now well established that BRCA1 and BRCA2-mutated women are at increased risk of breast and ovarian cancers. However, several lines of evidence indicate that this genetic status may also be associated with ovarian dysfunction, in particular a reduced ovarian reserve. Considering the gonadal toxicity of cancer treatments and the recommendation of prophylactic bilateral salpingo-oophorectomy around 40 years, young BRCA mutation carriers are confronted with difficult family planning decisions. Recent development in fertility preservation offers new possibilities for these women, not only before a potential cancer treatment, but also in healthy carriers. If the pregnancy seems to be safe in this population, oocyte vitrification following ovarian stimulation might help BRCA-mutated patients to conceive after cancer treatment or to undergo prenatal genetic diagnosis in order to avoid the risk of transmitting the genetic abnormality to their offspring. The present article aims to extensively discuss the fertility issues related to BRCA gene mutations and the questions raised by the possibility of fertility in this population. |
| Databáze: | OpenAIRE |
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