Increased inflammation in BA21 brain tissue from African Americans with Alzheimer’s disease
| Autor: | John J. Panos, Sherry A. Ferguson, Vijayalakshmi Varma, Daniel T. Sloper, Sumit Sarkar |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Chemokine medicine.medical_treatment Inflammation Biochemistry White People 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Alzheimer Disease Humans Medicine CX3CL1 Neuroinflammation Aged Aged 80 and over biology business.industry Inflammasome Temporal Lobe Black or African American 030104 developmental biology Cytokine Immunology biology.protein Female Neurology (clinical) CCL26 Inflammation Mediators medicine.symptom CCL25 business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Metabolic Brain Disease. 35:121-133 |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-019-00512-2 |
| Popis: | Chronic neuroinflammation is strongly associated with AD and altered peripheral and central levels of chemokines and cytokines have been frequently described in those with AD. Given the increasing evidence of ethnicity-related differences in AD, it was of interest to determine if those altered chemokine and cytokine levels are ethnicity-related. Because African Americans exhibit a higher incidence of AD and increased symptom severity, we explored chemokine and cytokine concentrations in post-mortem brain tissue from the BA21 region of African Americans and Caucasians with AD using multiplex assays. IL-1β, MIG, TRAIL, and FADD levels were significantly increased in African Americans while levels of IL-3 and IL-8 were significantly decreased. Those effects did not interact with gender; however, overall levels of CCL25, CCL26 and CX3CL1 were significantly decreased in women. The NLRP3 inflammasome is thought to be critically involved in AD. Increased activation of this inflammasome in African Americans is consistent with the current results. |
| Databáze: | OpenAIRE |
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