Effects of candidaemia on outcome of burns
| Autor: | A. Paugam, J. Stephanazzi, D. Wassermann, M. Benyamina, C Augris, M.T. Baixench, Sophie Grabar, Christophe Vinsonneau |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Antifungal Agents Urinary system Burn Units Microbial Sensitivity Tests Critical Care and Intensive Care Medicine Drug Resistance Fungal Bloodstream infection Internal medicine medicine Humans Candida albicans Mycosis Fungemia Candida Retrospective Studies biology business.industry Mortality rate Pharynx Candidiasis General Medicine Length of Stay Middle Aged medicine.disease biology.organism_classification Corpus albicans Surgery medicine.anatomical_structure Treatment Outcome Case-Control Studies Emergency Medicine Female business Burns |
| Zdroj: | Burns : journal of the International Society for Burn Injuries. 35(4) |
| ISSN: | 1879-1409 |
| Popis: | Aim To evaluate the diversity and antifungal susceptibilities of Candida isolates from wounds and blood of burn victims, and the associated mortality rates compared with those of controls without candidaemia. Methods We performed a nested case-control study within a database of clinical data for all patients admitted to our burn unit from January 2001 to December 2005. Each candidaemic patient was compared with two matched controls. Bloodstream cultures were performed if the core temperature was >39 °C, and three sites were cultured weekly for fungal identification (burn wound, pharynx, urinary tract). Results At least one episode of candidaemia was diagnosed among 20 of 851 persons admitted during the study period. Isolates in bloodstream infection were Candida albicans (65%), C. parapsilosis (25%) and C. tropicalis (10%). The median time between admission and onset of candidaemia was greater with C. albicans infection (42.6 ± 31 days) than with infection by other yeasts (18 ± 12 days). Candidaemia was associated with more extensive burn and longer duration of hospital stay but with similar mortality, compared with controls. Conclusion Candidaemia in burn cases is mostly due to fluconazole-susceptible C. albicans and is not associated with increased mortality. |
| Databáze: | OpenAIRE |
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