GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons
| Autor: | Susan Bektesh, Jack Lile, Daniel H. Doherty, Leu-Fen H. Lin, Frank H. Collins |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Cell Survival Dopamine Neurturin Molecular Sequence Data Persephin Nerve Tissue Proteins Cell Line Mesencephalon Neurotrophic factors Internal medicine medicine Glial cell line-derived neurotrophic factor Animals Humans Amino Acid Sequence Glial Cell Line-Derived Neurotrophic Factor Nerve Growth Factors Cloning Molecular Cells Cultured Cerebral dopamine neurotrophic factor Neurons Multidisciplinary Base Sequence biology urogenital system Dopaminergic Cell Differentiation Parkinson Disease Rats Cell biology Molecular Weight Endocrinology nervous system Proto-Oncogene Proteins c-ret Astrocytes biology.protein Neuroglia GDNF family of ligands |
| Zdroj: | Science. 260:1130-1132 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.8493557 |
| Popis: | A potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons was purified and cloned. Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake. These effects were relatively specific; GDNF did not increase total neuron or astrocyte numbers nor did it increase transmitter uptake by gamma-aminobutyric-containing and serotonergic neurons. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. |
| Databáze: | OpenAIRE |
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