Multivariate analysis of molecular indicators for postoperative liver metastasis in colorectal cancer cases
| Autor: | Ping Li, Shai-Hong Zhu, Li-yuan Qian, Xiao-Rong Li, Dao-Jin Chen |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Multivariate analysis MMP2 Epidemiology Colorectal cancer VEGF receptors Logistic regression Metastasis Immunoenzyme Techniques Internal medicine medicine Biomarkers Tumor Humans neoplasms Aged Aged 80 and over biology business.industry CD44 Liver Neoplasms Public Health Environmental and Occupational Health Middle Aged medicine.disease Prognosis digestive system diseases Lymphatic Metastasis biology.protein Immunohistochemistry Female business Colorectal Neoplasms |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 13(8) |
| ISSN: | 2476-762X |
| Popis: | Aims: To explore the relationship between various molecular makers and liver metastasis of colorectal cancer (CRC). Method: Using immunohistochemistry, protein expression of CEA, nm23, c-met, MMP2, COX2, VEGF, EGFR, and CD44 was assessed in 80 CRC cases. The Chi-square test and logistic regression were performed to analyze the relationship between these indicators and CRC liver metastasis. Results: There were significant differences in expression of CEA, MMP2, CD44, VEGF and EGFR between the liver metastasis and non metastasis groups (P < 0.05); no significant differences were noted for nm23, c-met, and COX-2 expression. Logistic regression analysis showed that only CEA, VEGF, and EGFR entered into the regression equation, and had significant correlations with CRC liver metastasis (α inclusion= 0.10, α elimination = 0.15, R2 = 0.718). Conclusions: Combination detection of CEA, VEGF, and EGFR may be an effective means to predict CRC liver metastasis. Nm23, c-met, MMP2, COX-2, and CD44, in contrast, are not suitable as prognostic markers. |
| Databáze: | OpenAIRE |
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