Human Genetic Determinants of Viral Diseases
| Autor: | Corine St. Gelais, James A. Dowdle, Leonia Bozzacco, Adam D. Kenney, Yan Sun, Jacob S. Yount, Matthew Z. Anderson, Amanda R. Panfil, Temet M. McMichael, Larry S. Schlesinger, Li Wu, Patrick L. Green, Carolina B. López, Brad R. Rosenberg |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Candidate gene viruses Adaptive Immunity Biology medicine.disease_cause Article Virus 03 medical and health sciences Receptors KIR Rotavirus Genetics medicine Humans Genetic Predisposition to Disease Parvovirus Human Genetics biology.organism_classification Virology Immunity Innate Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 030104 developmental biology Herpes simplex virus Gene Expression Regulation Virus Diseases Infectious disease (medical specialty) Host-Pathogen Interactions Interferon Regulatory Factors Norovirus Cytokines Receptors Virus Oncovirus Genome-Wide Association Study Signal Transduction |
| Zdroj: | Annual Review of Genetics. 51:241-263 |
| ISSN: | 1545-2948 0066-4197 |
| DOI: | 10.1146/annurev-genet-120116-023425 |
| Popis: | Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus–host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future. |
| Databáze: | OpenAIRE |
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