Genetic polymorphisms analysis of glutathione S-transferase M1 and T1 in children with acute lymphoblastic leukemia
| Autor: | Li Yuxiang, Zhang Li, Feng Jianfei, Hu Yu, Wang Jun, Wang Hong, Zhu Shaoxian |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Adolescent Genotype Biomedical Engineering Biology Biochemistry Polymerase Chain Reaction Biomaterials chemistry.chemical_compound Multiplex polymerase chain reaction Genetics medicine Humans Child Gene Childhood Acute Lymphoblastic Leukemia Earth-Surface Processes Glutathione Transferase Polymorphism Genetic Infant Glutathione Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease genomic DNA Leukemia Glutathione S-transferase chemistry Child Preschool biology.protein Female |
| Zdroj: | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 24(3) |
| ISSN: | 1672-0733 |
| Popis: | The relationship between glutathione S-transferases (GSTs) M1, T1 genotype and childhood acute lymphoblastic leukemia (ALL) was investigated. GSTM1 and GSTT1 genotypes in genomic DNA from 67 children with ALL and 146 healthy controls were analyzed by using the multiplex polymerase chain reaction (PCR). The frequencies of GSTM1, M1-T1 null genotypes in ALL children were significantly higher than in the healthy controls (76.12% versus 52.74%, OR=2.856, P0.001; 50.74% versus 24.66%, OR=3.148, P0.001, respectively). However, there was no significant relationship between GSTT1 null genotype and ALL of children (61.19% versus 49.32%, OR=1.621, P0.05). It was suggested that GSTM1 null genotype might be a risk genotype of childhood ALL, while there as no correlation between GSTT1 null genotype and childhood ALL. |
| Databáze: | OpenAIRE |
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