Risk factors for severe reactions in food allergy: rapid evidence review with meta‐analysis
| Autor: | Paul J, Turner, Stefania, Arasi, Barbara, Ballmer-Weber, Alessia, Baseggio Conrado, Antoine, Deschildre, Jennifer, Gerdts, Susanne, Halken, Antonella, Muraro, Nandinee, Patel, Ronald, Van Ree, Debra, de Silva, Margitta, Worm, Torsten, Zuberbier, Graham, Roberts |
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| Přispěvatelé: | Medical Research Council (MRC) |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Allergy Adolescent IGE ANTIBODIES Immunology severity macromolecular substances DOUBLE-BLIND Young Adult Risk Factors anaphylaxis Immunology and Allergy Humans ARA H 2 Child UNITED-KINGDOM food allergy Science & Technology OBJECTIVE SYMPTOMS Global Allergy Asthma European Network (GA2LEN) Food Allergy Guideline Group COMPONENT-RESOLVED DIAGNOSTICS GUT PERMEABILITY PEANUT ALLERGY biomarkers risk assessment Allergens nervous system Food 1107 Immunology Child Preschool HAZELNUT ALLERGY Life Sciences & Biomedicine Food Hypersensitivity FACTORS PREDICTING ANAPHYLAXIS |
| Popis: | This rapid review summarizes the most up to date evidence about the risk factors for severe food-induced allergic reactions. We searched three bibliographic databases for studies published between January 2010 and August 2021. We included 88 studies and synthesized the evidence narratively, undertaking meta-analysis where appropriate. Significant uncertainties remain with respect to the prediction of severe reactions, both anaphylaxis and/or severe anaphylaxis refractory to treatment. Prior anaphylaxis, an asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors. Some molecular allergology markers may be helpful. Hospital presentations for anaphylaxis are highest in young children, yet this age group appears at lower risk of severe outcomes. Risk of severe outcomes is greatest in adolescence and young adulthood, but the contribution of risk taking behaviour in contributing to severe outcomes is unclear. Evidence for an impact of cofactors on severity is lacking, although food-dependent exercise-induced anaphylaxis may be an exception. Some medications such as beta-blockers or ACE inhibitors may increase severity, but appear less important than age as a factor in life-threatening reactions. The relationship between dose of exposure and severity is unclear. Delays in symptom recognition and anaphylaxis treatment have been associated with more severe outcomes. An absence of prior anaphylaxis does not exclude its future risk. |
| Databáze: | OpenAIRE |
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