Structural and functional evolution of three cardiac natriuretic peptides
| Autor: | Nobuaki Okamoto, Sayaka Yamagami, Hozi Iwatani, Bruno Tota, Shinya Yuge, Takashi Sakamoto, Maria Carmela Cerra, Makiko Tsutsumi, Yoshio Takei, Hiroshi Hori, Koji Inoue, Norio Suzuki |
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| Rok vydání: | 2005 |
| Předmět: |
Untranslated region
animal structures DNA Complementary Molecular Sequence Data Biology Evolution Molecular Genetic linkage Complementary DNA Gene duplication Natriuretic Peptide Brain Genetics Animals Amino Acid Sequence Cloning Molecular Receptor Natriuretic Peptides Molecular Biology Gene Ecology Evolution Behavior and Systematics Sequence Homology Amino Acid Fishes Chromosome Mapping cardiovascular system Tandem exon duplication human activities hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor circulatory and respiratory physiology Hormone |
| Zdroj: | Molecular biology and evolution. 22(12) |
| ISSN: | 0737-4038 |
| Popis: | Natriuretic peptides (NPs) are a group of hormones playing important roles in cardiovascular and osmoregulatory systems in vertebrates. Among the NP subtypes, atrial NP (ANP), B-type NP (BNP), and ventricular NP (VNP) are circulating hormones expressed exclusively in the heart (cardiac NPs). The constitution of cardiac NPs is variable among species of vertebrates. In order to understand the evolutionary and functional significance of such variation, we performed a systematic survey of cardiac NP cDNAs in nine taxonomically diverse teleosts inhabiting environments of varying salinity. The discovery of the coexistence of the ANP, BNP, and VNP genes in the eel and rainbow trout suggested that the ancestral teleost had all three cardiac NPs. As the VNP cDNA was undetectable in ayu and six species of Neoteleostei, it is possible that VNP was lost before the divergence of Osmeroidei. The ANP gene was also undetectable in the medaka. Thus, only the BNP gene is universal in species examined in the present study. Synthetic medaka BNP preferentially activated two medaka GC-A-type receptors, suggesting that the three cardiac NPs share the same receptor. However, the regulation of BNP expression may be the most strict because ATTTA repeats in the 3'-untranslated region and the dibasic motif in the ring are conserved among teleosts and tetrapods. Linkage analyses in the rainbow trout located ANP, BNP, and VNP genes on the same chromosome, which suggested the generation of the VNP gene by tandem duplication as observed with ANP and BNP genes. If the duplication occurred before the divergence of tetrapods and teleosts, VNP may exist in the tetrapod lineage. |
| Databáze: | OpenAIRE |
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