Preexisting interstitial lung disease is inversely correlated to tumor epidermal growth factor receptor mutation in patients with lung adenocarcinoma
| Autor: | Keisuke Tomii, Takahisa Kawamura, Atsushi Nakagawa, Kosuke Tanaka, Junpei Takeshita, Kojiro Otsuka, Koji Tamai, Kyoko Otsuka, Hiroshi Hamakawa, Nobuyuki Katakami, Takeshi Matsumoto, Kazuya Monden, Ryo Tachikawa, Akito Hata, Yutaka Takahashi, Takehiro Otoshi, Yukihiro Imai, Kazuma Nagata, Daichi Fujimoto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Cancer Research Pathology medicine.medical_specialty High-resolution computed tomography Lung Neoplasms Adenocarcinoma of Lung Adenocarcinoma Idiopathic pulmonary fibrosis Usual interstitial pneumonia medicine Humans Epidermal growth factor receptor Idiopathic interstitial pneumonia Aged Aged 80 and over Lung medicine.diagnostic_test biology business.industry Interstitial lung disease Middle Aged respiratory system medicine.disease respiratory tract diseases ErbB Receptors medicine.anatomical_structure Oncology Mutation biology.protein Female Lung Diseases Interstitial Tomography X-Ray Computed business |
| Zdroj: | Lung Cancer. 80:159-164 |
| ISSN: | 0169-5002 |
| Popis: | Interstitial lung disease (ILD), especially idiopathic pulmonary fibrosis, has been shown to be associated with lung carcinogenesis. However, an association between epidermal growth factor receptor (EGFR) mutation status and preexisting ILD in patients with lung adenocarcinoma is unknown.Between January 2008 and April 2012, we analyzed 602 patients with lung adenocarcinoma. EGFR mutation status was analyzed using the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp method, and preexisting ILD was diagnosed based on clinical features, chest high-resolution computed tomography (HRCT) findings, and histological findings.There were 555 patients with pulmonary adenocarcinoma with tumor EGFR mutation data available for analysis. Of them, 31 patients (6%) had preexisting ILD, and EGFR mutations were detected in 246 of the 555 patients (46%). In the comparison between patients with EGFR mutations and those with wild-type EGFR, there was a significant inverse association between occurrence of tumors with EGFR mutations and ILD (1/246 vs. 30/309, P0.001). Based on the multivariate analysis of age, gender, smoking status, Eastern Cooperative Oncology Group Performance Status, stage, and ILD, EGFR mutations were found to be independently associated with females (OR, 1.58; 95% CI, 1.01-2.46; P=0.048), never-smokers (OR, 3.31; 95% CI, 2.12-5.20; P0.001), and the absence of ILD (OR, 17.41; 95% CI, 3.54-315.34; P0.001).This study showed that patients with pulmonary adenocarcinoma and ILD had a lower probability of carrying tumor EGFR mutations. |
| Databáze: | OpenAIRE |
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