Nanomaterials and autophagy: new insights in cancer treatment
| Autor: | Elisabetta Carata, Elisa Panzarini, Valentina Inguscio, Luciana Dini, Bernardetta Anna Tenuzzo |
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| Přispěvatelé: | Panzarini, Elisa, Inguscio, V, Tenuzzo, Ba, Carata, Elisabetta, Dini, Luciana |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Programmed cell death autophagy Cell Autophagy epigenetic factors Review Biology Bioinformatics lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens lcsh:RC254-282 Cancer treatment medicine.anatomical_structure Oncology Tumour development medicine Cancer research Nanomedicine cancer cancer therapy Intracellular Cell survival nanomaterials |
| Zdroj: | Cancers Cancers, Vol 5, Iss 1, Pp 296-319 (2013) |
| Popis: | Autophagy represents a cell's response to stress. It is an evolutionarily conserved process with diversified roles. Indeed, it controls intracellular homeostasis by degradation and/or recycling intracellular metabolic material, supplies energy, provides nutrients, eliminates cytotoxic materials and damaged proteins and organelles. Moreover, autophagy is involved in several diseases. Recent evidences support a relationship between several classes of nanomaterials and autophagy perturbation, both induction and blockade, in many biological models. In fact, the autophagic mechanism represents a common cellular response to nanomaterials. On the other hand, the dynamic nature of autophagy in cancer biology is an intriguing approach for cancer therapeutics, since during tumour development and therapy, autophagy has been reported to trigger both an early cell survival and a late cell death. The use of nanomaterials in cancer treatment to deliver chemotherapeutic drugs and target tumours is well known. Recently, autophagy modulation mediated by nanomaterials has become an appealing notion in nanomedicine therapeutics, since it can be exploited as adjuvant in chemotherapy or in the development of cancer vaccines or as a potential anti-cancer agent. Herein, we summarize the effects of nanomaterials on autophagic processes in cancer, also considering the therapeutic outcome of synergism between nanomaterials and autophagy to improve existing cancer therapies. |
| Databáze: | OpenAIRE |
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