Letrozole, an aromatase inhibitor, improves seminal parameters and hormonal profile in aged endangered Markhoz bucks
| Autor: | Asaad Vaziry, Abbas Farshad, Ako Rezaei |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Aromatase inhibitor
General Veterinary biology Physiology business.industry medicine.drug_class Letrozole Semen Sperm Andrology Serum luteinizing hormone Sex hormone-binding globulin Genetics biology.protein Medicine Animal Science and Zoology business Testosterone Food Science medicine.drug Hormone |
| Zdroj: | Animal Bioscience. 35:1666-1674 |
| ISSN: | 2765-0235 2765-0189 |
| Popis: | Objective: Letrozole, a potent aromatase inhibitor, is known to have the potential to modify male reproductive function by altering sex hormone levels. This study aimed to evaluate the semen and testicular characteristics and hormonal profile of aged Mrakhoz bucks (Capra hircus) treated with letrozole.Methods: Twelve Markhoz male goats, aged between 4.5 to 5.5 years with an average body weight (BW) of 61.05±4.97 kg were used for the study. Animals were randomly divided into two equal groups and subcutaneously received either 0.25 mg/kg BW of letrozole or a control every week for 2 months. The semen collections were performed every 10 days, and blood samples and testicular biometric records were collected at 20 days intervals.Results: Letrozole causes increased testosterone and follicle-stimulating hormone levels, testosterone to estradiol ratio, semen index and reaction time during the period from 20th to 60th days (p0.05). The serum luteinizing hormone levels, sperm viability, motility, and progressive motility increased, and estradiol levels decreased after 40th to 60th days of letrozole treatment (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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