Abnormalities in the evoked frontal oscillatory activity of first-episode psychosis: A TMS/EEG study
| Autor: | Adenauer G. Casali, Fabio Ferrarelli, Catarina Cardoso Reis, Bianca Graziano, Rachel E. Kaskie |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Psychosis Adolescent Electroencephalography behavioral disciplines and activities Young Adult 03 medical and health sciences 0302 clinical medicine First episode psychosis Humans Medicine Beta (finance) Biological Psychiatry medicine.diagnostic_test business.industry Motor Cortex Cortical neurons medicine.disease Transcranial Magnetic Stimulation Frontal Lobe 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Case-Control Studies Cortical oscillations Schizophrenia Female Chronic schizophrenia business Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Schizophrenia Research. 206:436-439 |
| ISSN: | 0920-9964 |
| Popis: | TMS with simultaneous EEG allows assessing the intrinsic oscillatory activity of cortical neurons. We recently showed reduced frontal cortical oscillations in chronic schizophrenia (SCZ). Here we investigated the oscillatory activity of first-episode psychosis (FEP) patients after TMS of a frontal area, the motor cortex. Compared to healthy controls, FEP patients had significantly reduced beta/low gamma oscillations, which were associated to worse clinical symptoms. Altogether, this study demonstrates that TMS/EEG recordings: 1) are feasible in acute, early-course psychotic patients; and 2) reveal intrinsic oscillatory deficits at illness onset, which may help design more effective, early interventions in SCZ. |
| Databáze: | OpenAIRE |
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