Octreotide long-acting repeatable and lanreotide Autogel are equally effective in controlling growth hormone secretion in acromegalic patients
| Autor: | Jan W. A. Smit, Marijke Frölich, B E P M Ballieux, Ferdinand Roelfsema, Nienke Biermasz, Alberto M. Pereira, Eleonora P M Corssmit, Johannes A. Romijn, S. W. van Thiel |
|---|---|
| Přispěvatelé: | Other departments |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Antineoplastic Agents Hormonal Endocrinology Diabetes and Metabolism Octreotide Lanreotide Peptides Cyclic chemistry.chemical_compound Endocrinology Pharmacokinetics Internal medicine Acromegaly medicine Humans Insulin-Like Growth Factor I Aged business.industry Somatostatin receptor Human Growth Hormone Lanreotide Autogel Anti-Inflammatory Agents Non-Steroidal General Medicine Middle Aged medicine.disease Growth hormone secretion Somatostatin chemistry Delayed-Action Preparations Female business medicine.drug |
| Zdroj: | European journal of endocrinology / European Federation of Endocrine Societies, 150(4), 489-495. BioScientifica Ltd. |
| ISSN: | 0804-4643 |
| Popis: | OBJECTIVE: Recently a new depot preparation of the long-acting somatostatin analogue, lanreotide Autogel was introduced for the treatment of acromegaly. Like octreotide long-acting repeatable (LAR), it has high binding affinity for the somatostatin receptor subtype SSTR 2 and less binding affinity for SSTR 5. We hypothesized that the ability to suppress growth hormone (GH) secretion in patients with acromegaly would be similar for these depot preparations. PATIENTS AND STUDY DESIGN: Seven patients (mean age+/-S.E.M. 48.4+/-7 years) on long-term octreotide LAR treatment at a monthly injection interval for a mean of 2.8 years were enrolled in the study. They underwent a GH secretory profile study with 10 min sampling for 24 h, 28 days after an injection. At 2, 4 and 6 weeks after the next injection fasting GH profiles (every 30 min for 3.5 h) and serum IGF-I measurements were measured. These investigations were repeated 12 months later, when the patients were on an individually titrated stable dose of lanreotide Autogel. RESULTS: Secretory characteristics and total 24 h GH secretion, estimated by deconvolution analysis of the 10 min 24 h plasma GH concentrations, did not show differences between these two long-acting somatostatin analogues. Both drugs were equally effective in GH and IGF-I suppression as measured at 2, 4 and also at 6 weeks following an injection. CONCLUSION: The efficacy of lanreotide Autogel and octreotide LAR was equal, notwithstanding that these drugs are administered in a different way and have different pharmacokinetics. |
| Databáze: | OpenAIRE |
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