How do topical nasal corticosteroids improve sleep and daytime somnolence in allergic rhinitis?
| Autor: | Christopher D. Hanks, L.H. Fisher, Timothy J. Craig |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Budesonide Allergy Rhinitis Allergic Perennial Adolescent Immunology Disorders of Excessive Somnolence Nasal congestion Double-Blind Method Adrenal Cortex Hormones medicine Flunisolide Humans Immunology and Allergy Administration Intranasal Aged Fluticasone Sleep disorder Cross-Over Studies business.industry Rhinitis Allergic Seasonal Middle Aged medicine.disease Anesthesia Nasal administration medicine.symptom Sleep business Somnolence medicine.drug |
| Zdroj: | Journal of Allergy and Clinical Immunology. 116:1264-1266 |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2005.10.009 |
| Popis: | Therapy for rhinitis improves sleep quality and symptoms of daytime sleepiness. This improvement with therapy may be secondary to anti-inflammatory effects, leading to a reduction of inflammatory mediators, or to a mechanical reduction of congestion directly leading to improvement in sleep disturbance. We combined our data from 3 placebo-controlled studies of intranasal corticosteroids in patients with perennial rhinitis to determine whether a correlation between the reduction of congestion and improved sleep and daytime somnolence existed. The pooled data of budesonide, flunisolide, and fluticasone demonstrated significantly decreased nasal congestion, sleep problems, and sleepiness in treated patients. The data demonstrated a correlation between a reduction in nasal congestion and an improvement of sleep (P.01) and daytime somnolence (P = .01). Thus, topical intranasal corticosteroids should be used to decrease nasal congestion and to improve sleep and daytime somnolence in patients manifesting these symptoms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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