Chitosan and its composites: Properties for use in bone substitution
| Autor: | Marek Stępniewski, Jerzy Gosk, Jacek Martynkiewicz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Calcium Phosphates
Scaffold Artificial bone Materials science Biocompatibility medicine.medical_treatment 02 engineering and technology 010402 general chemistry Bone morphogenetic protein 01 natural sciences Chitosan chemistry.chemical_compound Chitin medicine Animals Humans Composite material Growth factor General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Polybutylene succinate Durapatite chemistry Bone Substitutes 0210 nano-technology |
| Zdroj: | Polimery w medycynie. 47(1) |
| ISSN: | 0370-0747 |
| Popis: | For many years, research has been carried out on finding an ideal bone substitute. Chitosan (CTS) is a naturally occurring polysaccharide, obtained mainly from, inter alia, the shells of crustaceans. It is characterized by its high level of biocompatibility, biodegradability and antimicrobial properties as well as its support in the healing of wounds. Chitosan, due to its ability to form porous structures, can be used in the production of scaffolds used in the treatment of bone defects. There are numerous studies on the use of CTS in combination with other substances which aim to improve its biological and mechanical properties. The combination of chitosan with the calcium phosphate hydroxyapatite (HAp) has been extensively tested. The objective of the current studies is to verify the properties of scaffolds consisting of chitosan and other substances like polybutylene succinate, human bone marrow mesenchymal stem cells (hBMSCs), collagen, alginate, transforming growth factor - β (TGF-β), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF) or bone morphogenetic proteins (BMP). The aim of the current research is to develop a scaffold with sufficiently good mechanical properties. Trials are underway with many of the biological and synthetic components affecting the biological properties of chitosan. This will allow for the creation of a substitute that fully meets the conditions for an ideal artificial bone. |
| Databáze: | OpenAIRE |
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