In vitro and in vivo evaluation of three metronidazole topical products
| Autor: | Vinod P. Shah, Eva Benfeldt, Flavian Ştefan Rădulescu, Victor Voicu, Dalia Simona Miron |
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| Rok vydání: | 2013 |
| Předmět: |
Chemistry
Skin Absorption Area under the curve Pharmaceutical Science General Medicine Penetration (firestop) Pharmacology Bioequivalence Administration Cutaneous In vitro Dosage form Metronidazole Anti-Infective Agents In vivo Dermal microdialysis medicine Humans Pharmaceutical Vehicles Rheology medicine.drug Skin |
| Zdroj: | Pharmaceutical development and technology. 19(2) |
| ISSN: | 1097-9867 |
| Popis: | Two 1% and one 0.75% metronidazole cream products were approved as bioequivalent products. These products were evaluated for their in vivo cutaneous penetration characteristics by dermatopharmacokinetic (DPK) and dermal microdialysis (DMD) sampling methodologies. The same three products were also evaluated for their rheological and in vitro drug release (IVR) properties. Structural differences were observed in the resulting flow curves. However, similar IVR profiles were obtained for the two topical semisolid dosage forms containing 1% metronidazole. For the lower strength product, a higher IVR rate was associated with the lower DPK profile. All three products exhibited similar values of area under the curve when investigated by DMD. This in vitro evaluation corroborated the divergent penetration characteristics found using in vivo methodologies. |
| Databáze: | OpenAIRE |
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