Reversal by Triton WR-1339 of ethynyloestradiol-induced hepatic cholesterol esterification
| Autor: | Fred Kern, Radene Showalter, Roger A. Davis |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Sodium Sterol O-acyltransferase Phospholipid chemistry.chemical_element Blood lipids Ethinyl Estradiol Biochemistry Polyethylene Glycols chemistry.chemical_compound Internal medicine medicine Animals Molecular Biology Triglycerides Esterification Cholesterol Cellular Interactions and Control Processes Cell Biology Blood proteins Rats Endocrinology Liver chemistry Microsomes Liver Microsome Cholesteryl ester lipids (amino acids peptides and proteins) Cholesterol Esters Sterol O-Acyltransferase |
| Zdroj: | Biochemical Journal. 174:45-51 |
| ISSN: | 0264-6021 |
| DOI: | 10.1042/bj1740045 |
| Popis: | Rats treated with ethynyloestradiol have marked hypolipidaemia: serum cholesterol is decreased to 5%, triacylglycerol to 10% and phospholipid to 70% of control concentrations. Loss of serum cholesterol follows an exponential decay, with a half-life of 1.13±0.09 days. After 4 days of treatment, serum cholesterol concentrations remain relatively constant (ranging from 1 to 20mg/100ml) for at least 30 days. There is a concomitant 20-fold decrease in the d |
| Databáze: | OpenAIRE |
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