Randomized clinical trial of intra-operative antimicrobial prophylaxis of infection after neurosurgical procedures
| Autor: | Rivkah Shuval, Yehudit Kahane, Mordechai Shalit, Mervyn Shapiro, Uri Wald, Elisheva Simchen, David Zagzag, Ester Samuel-Cahn, Theodore Sacks, Shlomo Pomeranz, Yohanan Wax, Shlomo D. Michowiz |
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| Rok vydání: | 1986 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Urinary system Neurosurgery Placebo law.invention Intraoperative Period Random Allocation Postoperative Complications Randomized controlled trial Double-Blind Method law Vancomycin Sepsis Medicine Humans Surgical Wound Infection Meningitis Clinical Trials as Topic business.industry General Medicine Bacterial Infections Pneumonia Antimicrobial medicine.disease Cerebrospinal Fluid Shunts Surgery Anti-Bacterial Agents Clinical trial Infectious Diseases Anesthesia Urinary Tract Infections Gentamicin Female Gentamicins business medicine.drug |
| Zdroj: | The Journal of hospital infection. 8(3) |
| ISSN: | 0195-6701 |
| Popis: | A randomized, placebo-controlled, double-blind and sequentially analysed clinical trial to determine the efficacy of intra-operative parenteral gentamicin and vancomycin (with streptomycin in the irrigating solution) in preventing infection at the operative site following neurosurgical procedures is described. Patients receiving prophylaxis had a significantly (P = 0.046) lower operative site infection rate (2/71 = 2.8%) than those receiving placebo (9/77 = 11.7%). This difference was most apparent during an epidemic, the source of which was not evident. Moreover, a total of 13 infections (two operative site, five pneumonia and six urinary tract) occurred among 12 patients receiving prophylaxis, whereas there was a total of 31 infections (nine operative site, nine pneumonia, 10 urinary tract and three septicaemia) among 24 patients receiving placebo. A smaller quantity of antimicrobial drugs was administered postoperatively to patients receiving prophylaxis (3.96 'antibiotic-days' per patient) than to those receiving placebo (6.87 'antibiotic-days' per patient). |
| Databáze: | OpenAIRE |
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