6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58–2
| Autor: | Timothy J. O’Donnell, Rui Sun, Philip G. Williams, Alejandro M. S. Mayer, Wesley Y. Yoshida, Joshua R. Gurr, Yuheng Luo, Mary L Hall |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Lipopolysaccharides
Anti-Inflammatory Agents Pharmaceutical Science medicine.disease_cause Cyanobacteria 01 natural sciences Tolypodiol Article Analytical Chemistry chemistry.chemical_compound Mice Superoxides Drug Discovery medicine Escherichia coli Animals Edema Ear Diseases Pharmacology Strain (chemistry) Microglia 010405 organic chemistry Superoxide Organic Chemistry Absolute configuration In vitro 0104 chemical sciences Rats Thromboxane B2 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Complementary and alternative medicine Biochemistry chemistry Molecular Medicine Diterpenes |
| Zdroj: | J Nat Prod |
| Popis: | Chemical investigation of cyanobacterial strain HT-58–2, which most closely aligns with the genus Brasilomena, has led to the isolation of two compounds related to tolypodiol. The structures and absolute configuration of 6-deoxytolypodiol (1) and 11-hydroxytolypodiol (2) were elucidated by spectroscopic and spectrometric analysis. While tolypodiol previously showed anti-inflammatory activity in a mouse ear edema assay, only 2 reduced in vitro thromboxane B(2) (TXB(2)) and superoxide anion (O(2)(−)) generation from Escherichia coli lipopolysaccharide (LPS)-activated rat neonatal microglia to any appreciable degree. |
| Databáze: | OpenAIRE |
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