A1C Underestimates Glycemia in HIV Infection
| Autor: | Patrick Georgoff, Margo A. Smith, Colleen Hadigan, Peter Kim, Dana Crum, Alice Rosenberg, Christian Woods |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Blood sugar HIV Infections Type 2 diabetes chemistry.chemical_compound Abacavir Internal medicine Diabetes mellitus Internal Medicine medicine Humans Prospective Studies Prospective cohort study Mean corpuscular volume Original Research Glycated Hemoglobin Advanced and Specialized Nursing biology medicine.diagnostic_test business.industry Haptoglobin Clinical Care/Education/Nutrition/Psychosocial Research nutritional and metabolic diseases virus diseases Middle Aged medicine.disease Cross-Sectional Studies Fructosamine chemistry Multivariate Analysis Immunology biology.protein Female business medicine.drug |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc09-0177 |
| Popis: | OBJECTIVE The objective of this study was to determine the relationship between A1C and glycemia in HIV infection. RESEARCH DESIGN AND METHODS We completed a prospective cross-sectional study of 100 HIV-infected adults with type 2 diabetes (77%) or fasting hyperglycemia (23%) with measured glucose, A1C, mean corpuscular volume (MCV), and fructosamine. A total of 200 HIV-uninfected type 2 diabetic subjects matched for key demographic characteristics served as control subjects. RESULTS Relative to the control subjects, A1C underestimated glucose by 29 ± 4 mg/dl in the HIV-infected subjects. Current nucleoside reverse transcriptase inhibitors (NRTIs), higher MCV and hemoglobin, and lower HIV RNA and haptoglobin were associated with greater A1C-glucose discordance. However, only MCV and current NTRI use, in particular abacavir, remained significant predictors in multivariate analyses. Fructosamine more closely reflected glycemia in the HIV-infected subjects. CONCLUSIONS A1C underestimates glycemia in HIV-infected patients and is related to NRTI use. Use of abacavir and increased MCV were key correlates in multivariate analyses. Fructosamine may be more appropriate in this setting. |
| Databáze: | OpenAIRE |
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