Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3
| Autor: | Jin Tae Hong, Ju Ho Park, Ye Eun Choi, In Jun Yeo, Hyung Ok Jeon, Joo Kyung Song, Do Yeon Lee, Jung Eun Park, Jun Sung Jang, Jung Hun Joo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
STAT3 Transcription Factor Erythema Ultraviolet Rays Inflammation Dermatitis Enzyme-Linked Immunosorbent Assay Mice Transgenic Pharmacology medicine.disease_cause Carnosol STAT3 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Immune system Blood serum Drug Discovery medicine Animals Humans Sunburn skin and connective tissue diseases biology integumentary system Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Immunoglobulin E medicine.disease 030104 developmental biology chemistry 030220 oncology & carcinogenesis Abietanes biology.protein Molecular Medicine medicine.symptom UVB Oxidative stress Research Article |
| Zdroj: | Archives of Pharmacal Research |
| ISSN: | 0253-6269 |
| Popis: | Ultraviolet B (UVB) irradiation causes sunburn, inflammatory responses, dysregulation of immune function, oxidative stress, DNA damage and photocarcinogenesis on skin. Rosemary (Rosmarinus officinalis L.) has been reported to inhibit inflammation. Carnosol, a major component of Rosemary, has prominent anti-inflammatory effects. However, its protective effect on UVB-induced inflammatory skin responses has not yet been reported. Here, we investigated the effectiveness of carnosol on UVB-induced inflammation. We examined the anti-inflammation effect of topical application of carnosol (0.05 µg/cm2) on UVB (540 mJ/cm2, for 3 successive days)-induced skin inflammation in HR1 mice. Topical application of carnosol inhibited UVB-induced erythema, epidermal thickness, inflammatory responses in HR1 mice. Carnosol reduced the level of Immunoglobulin-E and IL-1β in blood serum of UVB-induced mice. Carnosol also significantly inhibited the UVB-induced expression of inflammatory marker protein (iNOS and COX-2) in back skin of mice. In addition, carnosol treated skin decreased activation of STAT3, a transcriptional factor regulating inflammatory genes. Our study suggested that carnosol has protective effects on skin inflammatory skin damages by UVB. |
| Databáze: | OpenAIRE |
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