Clinical characteristics and outcomes of COVID-19 in solid organ transplant recipients: A cohort study

Autor: Celeste T Williams, Jonathan D Williams, Mayur Ramesh, Amit T Vahia, Tommy Parraga Acosta, Milagros Samaniego-Picota, M Abouljoud, George J Alangaden, Odaliz Abreu-Lanfranco, Julio Pinto Corrales, Ramon Del Busto, Raef Fadel, Zohra S Chaudhry, Pritika Shrivastava, Shunji Nagai, Rohini Prashar, Nadeen J Khoury, Anita Patel
Rok vydání: 2020
Předmět:
Graft Rejection
Male
medicine.medical_specialty
infectious disease
medicine.medical_treatment
kidney transplantation/nephrology
Comorbidity
030230 surgery
clinical research/practice
law.invention
03 medical and health sciences
0302 clinical medicine
infection and infectious agents ‐ viral
Risk Factors
law
Internal medicine
medicine
Humans
Immunology and Allergy
organ transplantation in general
Pharmacology (medical)
Renal replacement therapy
Pandemics
Aged
Retrospective Studies
Immunosuppression Therapy
Mechanical ventilation
Transplantation
SARS-CoV-2
business.industry
Incidence
Acute kidney injury
COVID-19
Immunosuppression
Organ Transplantation
Original Articles
Odds ratio
Middle Aged
medicine.disease
Intensive care unit
Transplant Recipients
United States
complication: infectious
Intensive Care Units
Female
Original Article
business
Kidney disease
Cohort study
Zdroj: American Journal of Transplantation
ISSN: 1600-6135
Popis: Solid organ transplant recipients (SOTr) with coronavirus disease 2019 (COVID‐19) are expected to have poorer outcomes compared to nontransplant patients because of immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive hospitalized nontransplant controls. Twelve of 47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Chronic kidney disease (89% vs 57% P = .0007), diabetes (66% vs 33% P = .0007), and hypertension (94% vs 72% P = .006) were more common in the 35 hospitalized SOTr compared to controls. Diarrhea (54% vs 17%, P
Databáze: OpenAIRE
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