Long-chain polyunsaturated fatty acids improve airway pathological features and gut microbial imbalances in BALB/c mice with ovalbumin-induced asthma
| Autor: | Zhe Cheng, Di Sun, Pengfei Li, Xiaogang Jing, Shujun Wu, Lin An, Tianci Jiang, Junwei Zhao, Liuqun Jia, Yu Wang, Huan Wang, Meng Liu, Lingling Dai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Long-chain polyunsaturated fatty acids Medicine (miscellaneous) Gut microbiota Gut flora Pathological features BALB/c 03 medical and health sciences 0404 agricultural biotechnology Internal medicine medicine BALB/c mice TX341-641 Interleukin 5 Asthma chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics biology Nutrition. Foods and food supply Akkermansia 04 agricultural and veterinary sciences respiratory system medicine.disease biology.organism_classification 040401 food science respiratory tract diseases Ovalbumin Endocrinology chemistry biology.protein Methacholine Food Science medicine.drug Polyunsaturated fatty acid |
| Zdroj: | Journal of Functional Foods, Vol 81, Iss, Pp 104465-(2021) |
| ISSN: | 1756-4646 |
| Popis: | Long-chain polyunsaturated fatty acids (LCPUFAs) and the gut microbiota individually exert notable effects on asthma. However, it remains unknown whether LCPUFAs modulate the gut microbial composition. Twenty-four male BALB/c mice were randomly assigned to control (saline), asthma (ovalbumin (OVA)), and LCPUFAs groups (OVA plus LCPUFAs). The enhanced pause value was observed to decrease upon the administration of LCPUFAs in mice challenged with methacholine (12.5, 25, and 50 g/mL). LCPUFAs treatment decreased the number of eosinophils in BALF compared to that in non-treated asthmatic mice. The interleukin 5 levels in BALF and the airway PAS scores decreased after the asthmatic mice were treated with LCPUFAs. The treatment markedly reversed the imbalances in the gut microbial composition, as evidenced by the beta diversity analysis, and decreased the relative abundance of Akkermansia. These findings suggested that LCPUFAs modulated the gut microbial composition and improved airway pathological features in mice with OVA-induced asthma. |
| Databáze: | OpenAIRE |
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