Active information maintenance in working memory by a sensory cortex
| Autor: | Ruiqing Hou, Albert Compte, Wenjun Yan, Wenliang Wang, Chen Y, Hongmei Fan, Xiaoxing Zhang, Shumin Duan, Zhaoqin Chen, Chengyu Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Olfactory system
0301 basic medicine Mouse Computer science QH301-705.5 Science Piriform Cortex Sensory system Optogenetics behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology working memory Task (project management) Mice 03 medical and health sciences 0302 clinical medicine Piriform cortex medicine Animals Premovement neuronal activity anterior piriform cortex Sensory cortex Biology (General) optogenetics dual-task Neurons General Immunology and Microbiology Working memory General Neuroscience delay-period activity Electroencephalography General Medicine population neural activity Electrophysiology Memory Short-Term 030104 developmental biology medicine.anatomical_structure Medicine Psychology Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes Research Article |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | SummaryWorking memory is a critical function of the brain to maintain and manipulate information over delay periods of seconds. Sensory areas have been implicated in working memory; however, it is debated whether the delay-period activity of sensory regions is actively maintaining information or passively reflecting top-down inputs. We hereby examined the anterior piriform cortex, an olfactory cortex, in head-fixed mice performing a series of olfactory working memory tasks. Information maintenance is necessary in these tasks, especially in a dual-task paradigm in which mice are required to perform another distracting task while actively maintaining information during the delay period. Optogenetic suppression of the piriform cortex activity during the delay period impaired performance in all the tasks.Furthermore, electrophysiological recordings revealed that the delay-period activity of the anterior piriform cortex encoded odor information with or without the distracting task.Thus, this sensory cortex is critical for active information maintenance in working memory. |
| Databáze: | OpenAIRE |
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