Epistatic interactions can moderate the antigenic effect o substitutions in haemagglutinin of influenza H3N2 virus
| Autor: | David F. Burke, Stefan van der Vliet, Ron A. M. Fouchier, Björn F. Koel, Albert D. M. E. Osterhaus, Theo M. Bestebroer, Guus F. Rimmelzwaan, Derek J. Smith |
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| Přispěvatelé: | Virology, Medical Microbiology and Infection Prevention, AII - Infectious diseases |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
animal structures Short Communication viruses 030106 microbiology Hemagglutinin Glycoproteins Influenza Virus Context (language use) Biology complex mixtures Virus 03 medical and health sciences Antigen Virology Influenza Human Antigenic variation Humans Single amino acid Antigens Viral Viral antigens chemistry.chemical_classification Influenza A Virus H3N2 Subtype virus diseases Epistasis Genetic Amino acid 030104 developmental biology Amino Acid Substitution chemistry Epistasis Mutant Proteins sense organs |
| Zdroj: | Journal of General Virology, 100(5), 773-777. Microbiology Society Journal of general virology, 100(5), 773-777. Society for General Microbiology J Gen Virol |
| ISSN: | 0022-1317 |
| DOI: | 10.1099/jgv.0.001263 |
| Popis: | We previously showed that single amino acid substitutions at seven positions in haemagglutinin determined major antigenic change of influenza H3N2 virus. Here, the impact of two such substitutions was tested in 11 representative H3 haemagglutinins to investigate context-dependence effects. The antigenic effect of substitutions introduced at haemagglutinin position 145 was fully independent of the amino acid context of the representative haemagglutinins. Antigenic change caused by substitutions introduced at haemagglutinin position 155 was variable and context-dependent. Our results suggest that epistatic interactions with contextual amino acids in the haemagglutinin can moderate the magnitude of antigenic change. |
| Databáze: | OpenAIRE |
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