The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes
| Autor: | Fanny Jansson Sigfrids, Per-Henrik Groop, Steffen Thiel, Lena M. Thorn, Allan Flyvbjerg, Jakob Appel Østergaard, Valma Harjutsalo, Carol Forsblom, Troels Krarup Hansen, Emma H. Dahlström |
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| Přispěvatelé: | HUS Abdominal Center, Doctoral Programme in Clinical Research, Nefrologian yksikkö, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Institute for Molecular Medicine Finland, Helsinki University Hospital Area, Research Programs Unit, Department of General Practice and Primary Health Care, Department of Medicine, Per Henrik Groop / Principal Investigator, Clinicum |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Disease COMPLEMENT Comorbidities 0302 clinical medicine Chronic kidney disease Lectins Diabetic Nephropathies POPULATION Finland ALL-CAUSE MORTALITY VASCULAR COMPLICATIONS education.field_of_study Kidney diseases Multidisciplinary Diabetes Hazard ratio Models Cardiovascular Endocrine system and metabolic diseases ASSOCIATION Middle Aged 3. Good health DEFICIENCY Complement cascade Cardiovascular Diseases Medicine Female Ficolin IMMUNE COMPONENT FICOLIN-3 Adult medicine.medical_specialty Science Population Acute coronary syndromes Predictive markers Article 03 medical and health sciences Diabetes mellitus Internal medicine MANNOSE-BINDING LECTIN medicine Humans education Inflammation Type 1 diabetes Renal replacement therapy business.industry MICROALBUMINURIA medicine.disease Cardiovascular biology SEVERITY Diabetes Mellitus Type 1 030104 developmental biology Blood pressure Risk factors 3121 General medicine internal medicine and other clinical medicine Microalbuminuria business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Østergaard, J A, Jansson Sigfrids, F, Forsblom, C, Dahlström, E H, Thorn, L M, Harjutsalo, V, Flyvbjerg, A, Thiel, S, Hansen, T K & Groop, P H 2021, ' The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes ', Scientific Reports, vol. 11, no. 1, 8919 . https://doi.org/10.1038/s41598-021-88352-y Østergaard, J A, Jansson Sigfrids, F, Forsblom, C, Dahlström, E H, Thorn, L M, Harjutsalo, V, Flyvbjerg, A, Thiel, S, Hansen, T K & Groop, P-H 2021, ' The pattern-recognition molecule H-ficolin in relation to diabetic kidney disease, mortality, and cardiovascular events in type 1 diabetes ', Scientific Reports, vol. 11, no. 1, 8919 . https://doi.org/10.1038/s41598-021-88352-y Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| DOI: | 10.1038/s41598-021-88352-y |
| Popis: | H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18–1.40) and 1.16 (1.05–1.29) after adjustment for diabetes duration, sex, HbA1c, systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97–1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04–1.22) and 1.05 (0.93–1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05–1.35) and 1.18 (1.02–1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model. |
| Databáze: | OpenAIRE |
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