Primary Humoral Immune Responses to Formalin Inactivated Hemorrhagic Fever with Renal Syndrome Vaccine (Hantavax®): Consideration of Active Immunization in South Korea
| Autor: | Min Soo Park, Joung Soon Kim, Young Mo Sohn, Hye Ok Rho, Peter L. Summers |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Time Factors Antibodies Viral Vaccines Attenuated Active immunization Immune system Humans Medicine Seroconversion Neutralizing antibody Korea Hemagglutination assay biology business.industry Immunogenicity Vaccination Viral Vaccines General Medicine Middle Aged Virology Hantaan virus Immunoglobulin G Immunology biology.protein Antibody business |
| Zdroj: | Yonsei Medical Journal. 42:278 |
| ISSN: | 0513-5796 |
| DOI: | 10.3349/ymj.2001.42.3.278 |
| Popis: | The efficacy of a formalin-inactivated hemorrhagic fever with renal syndrome (HFRS) vaccine and the effectiveness of a related vaccination program have not been previously evaluated. We measured the primary immune responses to Hantavax by plaque reduction neutralizing antibody test (PRNT), hemagglutination inhibition test (HAI), ELISA and high density particle agglutination test (HDPA) in order to confirm a possible biological efficacy through independent substantiation of experimental results and to compare the results with previous studies. Following two doses of primary vaccination, the seroconversion rate of PRNT and HAI antibody was 33.3% (10/30) [95% C.I. 17.3-52.5%] and 26.7% (8/30) [95% C.I. 12.3-45.9%], respectively. The correlation between PRNT and HAI antibody showed a statistical significance (r=0.58, p |
| Databáze: | OpenAIRE |
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