Adiponectin and ischemia-reperfusion injury in ST segment elevation myocardial infarction
| Autor: | Tom Vandendriessche, Christiaan J. Vrints, Mark W Ronsyn, Vicky Y. Hoymans, Steven Haine, Hielko Miljoen, Bert R Everaert, Sarah Vandamme, Marc J. Claeys, Johan Bosmans, Lynn De Roeck, Guido R.Y. De Meyer, An M. Van Berendoncks |
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| Rok vydání: | 2015 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Myocardial Infarction Myocardial Reperfusion 030204 cardiovascular system & hematology Coronary Angiography Critical Care and Intensive Care Medicine Electrocardiography 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Predictive Value of Tests Internal medicine Outcome Assessment Health Care medicine Humans ST segment Prospective Studies cardiovascular diseases Myocardial infarction Aged Adiponectin medicine.diagnostic_test business.industry Pharmacology. Therapy Percutaneous coronary intervention General Medicine Middle Aged medicine.disease 030104 developmental biology Reperfusion Injury Cardiology Female Human medicine Cardiology and Cardiovascular Medicine business Reperfusion injury Mace TIMI |
| Zdroj: | European heart journal : acute cardiovascular care |
| ISSN: | 2048-8734 2048-8726 |
| DOI: | 10.1177/2048872615570770 |
| Popis: | Background: Models of experimental ischemia-reperfusion (IR) in adiponectin knockout animals have shown that adiponectin mediates protection against the development of IR injury. However, the role of adiponectin in IR injury in humans is largely unknown. Methods: In a total of 234 ST segment elevation myocardial infarction (STEMI) patients, baseline circulating total adiponectin concentration was correlated with IR injury after primary percutaneous coronary intervention (pPCI) and with major adverse cardiac events (MACE, death and cardiac hospitalization) during one year of follow up. IR injury was defined by serial electrocardiography (ECG) as >30% persistent ST segment elevation despite successful restoration of vessel patency and by angiography as thrombolysis in myocardial infarction (TIMI) blush grade |
| Databáze: | OpenAIRE |
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