Comparison of the anti-inflammatory potency and local tolerance of diclofenac and indomethacin eye drops in the postoperative management of patients undergoing ECCE with PCL
| Autor: | B. Blumer, H. E. Killer, M. Mayers |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
genetic structures
biology business.industry medicine.drug_class medicine.medical_treatment Inflammation Cataract surgery eye diseases Anti-inflammatory Postoperative management Ophthalmology Diclofenac Anesthesia LOCAL TOLERANCE medicine biology.protein Immunology and Allergy Potency Cyclooxygenase medicine.symptom business medicine.drug |
| Zdroj: | Ocular immunology and inflammation. 1(3) |
| ISSN: | 0927-3948 |
| Popis: | Prostaglandins have been shown to mediate various manifestations of ocular inflammation. Diclofenac and indomethacin are thought to inhibit cyclooxygenase, an enzyme necessary for prostaglandin biosynthesis. The anti-inflammatory effect and subjective tolerance of topical diclofenac 0.1% and indomethacin 0.1% were examined in the postoperative treatment of 64 patients undergoing extracapsular cataract surgery with IOL implantation in a prospective, comparative, single masked study. Patients with preexisting ocular disease or whose intraoperative course was complicated were excluded from the study. Ophthalmologic examinations were performed preoperatively and at days: 1, 4-6, and 28-30 post surgery. Tolerance was assessed by subjective patient evaluation. There was no significant difference (p < 0.05) in postoperative inflammation among the two treatment groups. There was a trend for more severe corneal edema on day 4-6 in the indomethacin group. Diclofenac was slightly better tolerated. |
| Databáze: | OpenAIRE |
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