Effect of 17β-Estradiol on Plasma Lipids and LDL Oxidation in Postmenopausal Women With Type II Diabetes Mellitus
| Autor: | Hans M.G. Princen, H. Michiel J. Krans, R. Buytenhek, Arnoud van der Laarse, H.E. Brussaard, Wim van Duyvenvoorde, Cornelis Kluft, Jan A. Gevers Leuven |
|---|---|
| Přispěvatelé: | TNO Preventie en Gezondheid |
| Rok vydání: | 1997 |
| Předmět: |
Apolipoprotein B
Low density lipoprotein Coronary risk chemistry.chemical_compound Controlled clinical trial Blood plasma Insulin Apolipoprotein a1 Sulfonylurea derivative Treatment outcome Apolipoprotein b High density lipoprotein cholesterol Estradiol biology Double blind procedure Middle Aged Lipids Lipoproteins LDL Postmenopause Hemoglobin A Randomized controlled trial Low-density lipoprotein Female lipids (amino acids peptides and proteins) Apolipoprotein A1 Antioxidant Cardiology and Cardiovascular Medicine Hormonal regulation Oxidation-Reduction Adult medicine.medical_specialty Plasma lipid Hemoglobin a Triacylglycerol Oral drug administration Metabolic regulation Internal medicine Diabetes mellitus Oxidation medicine Humans Human tissue Particle Size Biology Lipoprotein metabolism Aged Cholesterol business.industry nutritional and metabolic diseases 17β- estradiol medicine.disease Endocrinology Human cell Diabetes Mellitus Type 2 chemistry Non-insulin-dependent diabetes mellitus biology.protein Non insulin dependent diabetes mellitus Glycated hemoglobin LDL oxidation business Controlled study |
| Zdroj: | Scopus-Elsevier Arteriosclerosis, Thrombosis, and Vascular Biology, 2, 17, 324-330 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.17.2.324 |
| Popis: | In type II diabetes mellitus the altered hormonal state after menopause may represent an additional cardiovascular risk factor. Estrogen replacement therapy (ERT) is associated with a decreased cardiovascular risk, at least in nondiabetic postmenopausal women. We studied the effect of ERT on plasma lipids and lipoproteins and on LDL oxidation in 40 postmenopausal women with type II diabetes but with minimal vascular complications in a randomized placebo-controlled trial. Twenty patients were treated orally with 2 mg/d micronized 17β-estradiol and 20 patients with placebo for 6 weeks. Plasma total cholesterol (−6%, P =.04), LDL cholesterol (−16%, P =.0001), and apoB (−11%, P =.001) levels decreased and HDL cholesterol (20%, P =.0001) and apoA-I (14%, P =.0001) levels increased after ERT compared with placebo. Glycated hemoglobin (HbA1c) decreased significantly after ERT (−3%, P =.03), the cholesterol content of the LDL particles decreased (−5%, P =.006), triglyceride content increased (16%, P =.01), and LDL particle size did not change significantly. ERT had no effect on parameters of LDL oxidation. We conclude that plasma levels of HDL cholesterol, apoA-I, LDL cholesterol, apoB, and glycated hemoglobin are improved in postmenopausal women with type II diabetes mellitus after treatment with 17β-estradiol, indicative of a better metabolic control, and that ERT has no effect on LDL oxidizability. |
| Databáze: | OpenAIRE |
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