How to control an intracellular proteolytic system: Coordinated regulatory switches in the mycobacterial Pup-proteasome system
| Autor: | Yifat Elharar, Maayan Korman, Eyal Gur, Ofir Regev, Shai Schlussel, Nir Hecht, Nimrod Silberberg |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proteasome Endopeptidase Complex medicine.diagnostic_test Bacteria Ubiquitin Proteolysis 030106 microbiology Eukaryota Cell Biology Biology Protein degradation 03 medical and health sciences 030104 developmental biology Proteasome Biochemistry medicine System level Control (linguistics) Molecular Biology Neuroscience Intracellular |
| Zdroj: | Biochimica et biophysica acta. Molecular cell research. 1864(12) |
| ISSN: | 0167-4889 |
| Popis: | Intracellular proteolysis is critical for the proper functioning of all cells, owing to its involvement in a wide range of processes. Because of the destructive nature of protein degradation, intracellular proteolysis is restricted by control mechanisms at almost every step of the proteolytic process. Understanding the coordination of such mechanisms is a challenging task, especially in systems as complex as the eukaryotic ubiquitin-proteasome system (UPS). In comparison, the bacterial analog of the UPS, the Pup-proteasome system (PPS) is much simpler and, therefore, allows for insight into the control of a proteolytic system. This review integrates available information to present a coherent picture of what is known of PPS regulatory switches and describes how these switches act in concert to enforce regulation at the system level. Finally, open questions regarding PPS regulation are discussed, providing readers with a sense of what lies ahead in the field. |
| Databáze: | OpenAIRE |
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