Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity
| Autor: | Hyun-A Kim, H. Lee, Yong-Ho Jung, Sang Won Park, J. S. Son, Nam Joong Kim, Won Sup Oh, Won Suk Choi, Ju-Hyeon Choi, Yeon Sook Kim, Chan-Sub Kim, Ju-Young Yoon, H. Y. Seol, J. H. Lee, Hee-Chang Jang, Sungman Park, Sukjae Jeong, Yong-Su Choi, Sang-Sam Choi, Heungjeong Woo, Kyo-Young Lee, Jung-Ran Choi, Hyukjae Choi, Ji Hwan Bang, Sun-Mi Choi, Jinseon Kim, Sungmin Kiem, Sung Hwan Park, Jeewon Rhee, Kye-Hyung Kim, Yu Mi Wi, Eu Suk Kim, Baek-Nam Kim |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Infectious Disease Transmission Patient-to-Professional Adolescent IgG Middle East respiratory syndrome coronavirus Health Personnel health care facilities manpower and services education 030106 microbiology medicine.disease_cause Article Serology Young Adult 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Personal protective equipment Internal medicine medicine Healthcare personnel Humans Seroprevalence 030212 general & internal medicine Aged Indirect immunofluorescence Transmission (medicine) business.industry Incidence Middle East respiratory syndrome Incidence (epidemiology) virus diseases General Medicine Middle Aged medicine.disease Health Surveys Virology Infectious Diseases Population Surveillance Middle East Respiratory Syndrome Coronavirus Female Coronavirus Infections business |
| Zdroj: | Clinical Microbiology and Infection |
| ISSN: | 1198-743X |
| Popis: | Given the mode of transmission of Middle East respiratory syndrome (MERS), healthcare workers (HCWs) in contact with MERS patients are expected to be at risk of MERS infections. We evaluated the prevalence of MERS coronavirus (CoV) immunoglobulin (Ig) G in HCWs exposed to MERS patients and calculated the incidence of MERS-affected cases in HCWs. We enrolled HCWs from hospitals where confirmed MERS patients had visited. Serum was collected 4 to 6 weeks after the last contact with a confirmed MERS patient. We performed an enzyme-linked immunosorbent assay (ELISA) to screen for the presence of MERS-CoV IgG and an indirect immunofluorescence test (IIFT) to confirm MERS-CoV IgG. We used a questionnaire to collect information regarding the exposure. We calculated the incidence of MERS-affected cases by dividing the sum of PCR-confirmed and serology-confirmed cases by the number of exposed HCWs in participating hospitals. In total, 1169 HCWs in 31 hospitals had contact with 114 MERS patients, and among the HCWs, 15 were PCR-confirmed MERS cases in study hospitals. Serologic analysis was performed for 737 participants. ELISA was positive in five participants and borderline for seven. IIFT was positive for two (0.3%) of these 12 participants. Among the participants who did not use appropriate personal protective equipment (PPE), seropositivity was 0.7% (2/294) compared to 0% (0/443) in cases with appropriate PPE use. The incidence of MERS infection in HCWs was 1.5% (17/1169). The seroprevalence of MERS-CoV IgG among HCWs was higher among participants who did not use appropriate PPE. |
| Databáze: | OpenAIRE |
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