Inflammation-associated miR-155 activates differentiation of muscular satellite cells
Autor: | Maki Itokazu, Toshiyuki Takehara, Tatsufumi Mori, Takeshi Teramura, Yuta Onodera, Kanji Fukuda |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Critical Care and Emergency Medicine Cellular differentiation Gene Expression lcsh:Medicine Pathology and Laboratory Medicine Biochemistry Geographical Locations Mice Japan Cell Movement Animal Cells Morphogenesis Medicine and Health Sciences Receptor Notch1 lcsh:Science Immune Response Cells Cultured Cellular Senescence Trauma Medicine Multidisciplinary Stem Cells Cell Differentiation Muscle Differentiation Up-Regulation Cell biology Nucleic acids Cellular Types Stem cell medicine.symptom Traumatic Injury Research Article Asia Satellite Cells Skeletal Muscle Immunology Inflammation Biology miR-155 03 medical and health sciences Signs and Symptoms Multinucleate Downregulation and upregulation Diagnostic Medicine microRNA Genetics medicine Animals Non-coding RNA Cell Proliferation Cell growth CCAAT-Enhancer-Binding Protein-beta lcsh:R Biology and Life Sciences Cell Biology Gene regulation MicroRNAs 030104 developmental biology Musculoskeletal Injury People and Places RNA lcsh:Q Developmental Biology |
Zdroj: | PLoS ONE, Vol 13, Iss 10, p e0204860 (2018) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | Tissue renewal and muscle regeneration largely rely on the proliferation and differentiation of muscle stem cells called muscular satellite cells (MuSCs). MuSCs are normally quiescent, but they are activated in response to various stimuli, such as inflammation. Activated MuSCs proliferate, migrate, differentiate, and fuse to form multinucleate myofibers. Meanwhile, inappropriate cues for MuSC activation induce premature differentiation and bring about stem cell loss. Recent studies revealed that stem cell regulation is disrupted in various aged tissues. We found that the expression of microRNA (miR)-155, which is an inflammation-associated miR, is upregulated in MuSCs of aged muscles, and this upregulation activates the differentiation process through suppression of C/ebpβ, which is an important molecule for maintaining MuSC self-renewal. We also found that Notch1 considerably repressed miR-155 expression, and loss of Notch1 induced miR-155 overexpression. Our findings suggest that miR-155 can act as an activator of muscular differentiation and might be responsible for accelerating aging-associated premature differentiation of MuSCs. |
Databáze: | OpenAIRE |
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