Icariin Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension via the Inhibition of TGF-β1/Smads Pathway in Rats
| Autor: | Yijia Xiang, Lebing Yang, Chunlai Zeng, Shiyong Ye, Huan Zhao, Changhong Cai, Yonghui Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
MMP2 Article Subject 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound Other systems of medicine 0302 clinical medicine Right ventricular hypertrophy Internal medicine medicine.artery medicine 030304 developmental biology 0303 health sciences Lung business.industry medicine.disease medicine.anatomical_structure Endocrinology Complementary and alternative medicine chemistry Pulmonary artery Ventricular pressure Myocardial fibrosis business Icariin RZ201-999 Transforming growth factor Research Article |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 |
| Popis: | Background. Pulmonary artery remodeling is important in the development of pulmonary artery hypertension. The TGF-β1/Smads signaling pathway is activated in pulmonary arterial hypertension (PAH) in rats. Icariin (ICA) suppresses the TGF-β1/Smad2 pathway in myocardial fibrosis in rats. Therefore, we investigated the role of icariin in PAH by inhibiting the TGF-β1/Smads pathway. Methods. Rats were randomly divided into control, monocrotaline (MCT), MCT + ICA-low, and MCT + ICA-high groups. MCT (60 mg/kg) was subcutaneously injected to induce PAH, and icariin (50 or 100 mg/kg.d) was orally administered for 2 weeks. At the end of the fourth week, right ventricular systolic pressure (RVSP) was obtained and the right ventricular hypertrophy index (RI) was determined as the ratio of the right ventricular weight to the left ventricular plus septal weight (RV/LV + S). Western blots were used to determine the expression of TGF-β1, Smad2/3, P-Smad2/3, and matrix metalloproteinase-2 (MMP2) in lung tissues. Results. Compared to the control group, RVSP and RI were increased in the MCT group (ρ |
| Databáze: | OpenAIRE |
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