| Autor: |
Cheng Ma, Xin Qi, Yi-Fan Wei, Zhi Li, He-Long Zhang, He Li, Feng-Lei Yu, Ya-Nan Pu, Yong-Can Huang, Yong-Xin Ren |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Bioactive materials. 19 |
| ISSN: |
2452-199X |
| Popis: |
Ligamentum flavum (LF) hypertrophy (LFH) has been recognised as one of the key contributors to lumbar spinal stenosis. Currently, no effective methods are available to ameliorate this hypertrophy. In this study, human umbilical cord mesenchymal stromal cell-derived extracellular vesicles (hUCMSC-EVs) were introduced for the first time as promising vehicles for drug delivery to treat LFH. The downregulation of miR-146a-5p and miR-221-3p expressions in human LF tissues negatively correlated with increased LF thickness. The hUCMSC-EVs enriched with these two miRNAs significantly suppressed LFH |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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