Effect of various treatments on leptin, adiponectin, ghrelin and neuropeptide Y in patients with type 2 diabetes mellitus
| Autor: | Dimitri P. Mikhailidis, John G. Yovos, Dimitrios T. Karamitsos, Niki Katsiki, Anna Gotzamani-Psarrakou |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Leptin
Male medicine.medical_specialty endocrine system diseases medicine.medical_treatment Clinical Biochemistry Internal medicine Diabetes mellitus Drug Discovery medicine Humans Hypoglycemic Agents Neuropeptide Y Pharmacology Adiponectin business.industry Insulin digestive oral and skin physiology nutritional and metabolic diseases Type 2 Diabetes Mellitus Neuropeptide Y receptor medicine.disease Obesity Ghrelin Endocrinology Diabetes Mellitus Type 2 Molecular Medicine Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Expert Opinion on Therapeutic Targets. 15:401-420 |
| ISSN: | 1744-7631 1472-8222 |
| DOI: | 10.1517/14728222.2011.553609 |
| Popis: | Several peptides are involved in the regulation of food intake and energy expenditure, among which are leptin, adiponectin, ghrelin and neuropeptide Y (NPY). These peptides may be implicated in the obesity seen in the majority of patients with type 2 diabetes mellitus (T2DM).The present review considers: i) the role of leptin, adiponectin, ghrelin and NPY in patients with T2DM, and, ii) the effect of insulin as well as oral hypoglycemic, antihypertensive, hypolipidemic, antiobesity and antiplatelet agents on these peptides in patients with T2DM.Patients with T2DM have either lower or similar leptin levels, decreased adiponectin and ghrelin levels, and increased NPY circulating levels compared with nondiabetic controls. Treatment with insulin, oral hypoglycemic, antihypertensive, hypolipidemic, antiobesity and antiplatelet drugs may influence the levels of these peptides. It is not widely appreciated that several drugs commonly administered to patients with T2DM can influence adipokine levels. The clinical relevance of these effects needs to be evaluated. |
| Databáze: | OpenAIRE |
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