Itch in Psoriasis: A New Look at Well-known Subject
| Autor: | Rafał Białynicki-Birula, Radomir Reszke, Jacek C Szepietowski |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Allopurinol Dermatology Disease Comorbidity pharmacotherapy Logistic regression comorbidities elderly 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Risk Factors Psoriasis Surveys and Questionnaires otorhinolaryngologic diseases lcsh:Dermatology Prevalence Medicine Humans itch skin and connective tissue diseases Asthma Aged Aspirin business.industry Pruritus Age Factors General Medicine lcsh:RL1-803 Middle Aged medicine.disease 030104 developmental biology Cross-Sectional Studies Chronic Disease Itching Female Poland medicine.symptom business medicine.drug |
| Zdroj: | Acta Dermato-Venereologica, Vol 99, Iss 4, Pp 429-434 (2019) |
| ISSN: | 1651-2057 |
| Popis: | Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of subjects. Patients aged 65 years and over presented higher 4-Item Itch Questionnaire (4IIQ) scores (8.6 ± 3.4 vs. 7.4 ± 2.5 points; p = 0.03) and rarely experienced itching at midday (p = 0.009). Chronic itch correlated with aspirin intake and xerosis intensity. 4IIQ scores were higher in patients with asthma/chronic obstructive pulmonary disease, peptic ulcer disease and those taking insulin. Logistic regression analysis found that chronic itch was positively correlated with the use of antacids, angiotensin receptor blockers, angiotensin enzyme converting inhibitors, beta-blockers, xerosis intensity and Physician's Global Assessment score, whereas psychiatric drugs other than selective serotonin reuptake inhibitors, allopurinol, coexistence of arterial hypertension and application of emollients acted conversely. Elderly psoriatic patients present several differences in the characteristics of chronic itch, and chronic itch may be associated with comorbidities and pharmacotherapy. To the best of our knowledge, this is the first study to report possible associations between psoriatic pruritus and co-administration of drugs utilized in various systemic conditions. |
| Databáze: | OpenAIRE |
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