Relationship between glycated albumin and glycated hemoglobin according to glucose tolerance status: A multicenter study

Autor: Yongde Peng, Xin Gao, Wenying Yang, Yanbing Li, Qiang Li, Weiping Jia, Yifei Mo, Jian Zhou, Hong Li, Xiaojing Ma, Yun Xie, Weiqing Wang, Xiaojun Luan, Xing-Wu Ran
Rok vydání: 2015
Předmět:
Adult
Glycation End Products
Advanced
Male
medicine.medical_specialty
endocrine system diseases
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Type 2 diabetes
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Endocrinology
Glycated albumin
Intervention (counseling)
Internal medicine
Diabetes mellitus
Glucose Intolerance
Internal Medicine
Medicine
Chinese subjects
Humans
Insulin
Glycated Serum Albumin
Prediabetes
Serum Albumin
Aged
Aged
80 and over
Glycated Hemoglobin
business.industry
nutritional and metabolic diseases
General Medicine
Glucose Tolerance Test
Middle Aged
medicine.disease
Postprandial
Cross-Sectional Studies
chemistry
Multicenter study
Diabetes Mellitus
Type 2
Blood sugar regulation
Female
Glycated hemoglobin
business
Zdroj: Diabetes research and clinical practice. 115
ISSN: 1872-8227
Popis: To determine the relationship between glycated albumin (GA) and glycated hemoglobin (HbA1c) and to explore the association of glycated albumin/glycated hemoglobin (GA/HbA1c) ratio with glucose indices in Chinese subjects with varying glucose tolerance status.This hospital-based, cross-sectional study involved 953 participants without known diabetes from 11 centers in China. Oral glucose tolerance test (OGTT) was used to identify three groups of subjects: normal glucose regulation (n=194), impaired glucose regulation (n=303) and newly diagnosed type 2 diabetes group (n=456). The GA, HbA1c and GA/HbA1c ratio were tested.GA was positively correlated with HbA1c (r=0.832, P0.001). After correcting for age, sex and BMI, the correlations remained significant (r=0.824, P0.001). Linear regression analysis estimated that a 1% increase of HbA1c was associated with a 2.84% increase of GA (GA=2.843×HbA1c-0.203; R(2)=0.692, P0.001). GA would be 18.3 (16.7-19.9)% and 19.7 (18.0-21.4)% with HbA1c of 6.5% (48mmol/mol) and 7.0% (53mmol/mol). The mean GA/HbA1c ratio was 2.81±0.38, and it significantly increased with the presence of glucose intolerance (all, P0.05). In the total study population, GA/HbA1c was correlated with BMI, glucose levels and 30-min insulin during OGTT, the homeostatic model assessment of β-cell function (HOMA-β), and ΔI30/ΔG30 (all, P0.05). Increased glucose at 30min (standardized β=0.221, P0.001), and decreased BMI (standardized β=-0.114, P=0.008) were associated with elevated GA/HbA1c ratio by multiple linear regression (adjusted R(2)=0.045).The relationship between GA and HbA1c was strong. The GA/HbA1c ratio was related to acute postprandial glucose fluctuation and BMI level.
Databáze: OpenAIRE
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