Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 - An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives

Autor: Alin Laurentiu Tatu, Thomas Nadasdy, Anca Arbune, Valentin Chioncel, Carmen Bobeica, Elena Niculet, Alina Viorica Iancu, Caterina Dumitru, Valentin Tudor Popa, Nicolas Kluger, Victor Gabriel Clatici, Claudiu Ionut Vasile, Cristian Onisor, Alexandru Nechifor
Rok vydání: 2022
Předmět:
Zdroj: Journal of inflammation research. 15
ISSN: 1178-7031
Popis: The interrelations and sequencing of interleukins are complex (inter)actions where each interleukin can stimulate the secretion of its preceding interleukin. In this paper, we attempt to summarize the currently known roles of IL-4, IL-13, IL-31, and IL-33 from a multi-disciplinary perspective. In order to conduct a comprehensive review of the current literature, a search was conducted using PubMed, Google Scholar, Medscape, UpToDate, and Key Elsevier for keywords. The results were compiled from case reports, case series, letters, and literature review papers, and analyzed by a panel of multi-disciplinary specialist physicians for relevance. Based on 173 results, we compiled the following review of interleukin signaling and its clinical significance across a multitude of medical specialties. Interleukins are at the bed rock of a multitude of pathologies across different organ systems and understanding their role will likely lead to novel treatments and better outcomes for our patients. New interleukins are being described, and the role of this inflammatory cascade is still coming to light. We hope this multi-discipline review on the role interleukins play in current pathology assists in this scope.
Databáze: OpenAIRE