Performance of a Multidisciplinary Pancreatic Cancer Conference in Predicting and Managing Resectable Pancreatic Cancer
| Autor: | Alexander V. Kirichenko, Donald Atkinson, Harry Williams, Suzanne Morrissey, Abhijit Kulkarni, Shailendra Singh, Manav Sharma, Ghita Moussiade, Aslam Syed, Shyam Thakkar, Marcia Mitre, Bharat Rao, Mrinal Garg, Abhishek Gulati, Manish Dhawan, Amy Tang, Suzanne Schiffman, Anthony Lupetin, Dulabh Monga |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Resectable Pancreatic Cancer medicine.medical_specialty Pancreatic ductal adenocarcinoma Consensus Development Conferences as Topic Endocrinology Diabetes and Metabolism Stage ii 03 medical and health sciences Pancreatectomy 0302 clinical medicine Endocrinology Pancreatic cancer Outcome Assessment Health Care Internal Medicine Carcinoma medicine Humans Prospective Studies Stage (cooking) Prospective cohort study Aged Hepatology Tumor size business.industry Middle Aged Prognosis medicine.disease Pancreatic Neoplasms 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology Radiology business Carcinoma Pancreatic Ductal |
| Zdroj: | Pancreas. 48:80-84 |
| ISSN: | 1536-4828 0885-3177 |
| DOI: | 10.1097/mpa.0000000000001209 |
| Popis: | Objectives Surgery is the curative treatment for pancreatic ductal adenocarcinoma (PDA). Guidelines recommend utilizing a multidisciplinary pancreatic cancer conference (MDPC) in treatment; however, data are limited. The objective of this study was to assess the accuracy of an MDPC. Methods Patients with PDA presented at an MDPC were prospectively collected from April 2013 to August 2016. Patients were included if the MDPC predicted them to have resectable PDA and underwent upfront surgery. Secondary aims were to compare differences in tumor characteristics, time to surgery, and resection rates with patients prior to MDPC implementation (pre-MDPC). Results A total of 278 patients were presented at the MDPC. After excluding borderline and nonresectable cases, 91 patients were predicted as resectable on evaluation, and 70 were fit for surgery. The MDPC predicted resection in 91.4%. The MDPC had larger tumor size (32.6 vs 24.0 mm), greater proportion of stage II tumor, and a shorter time from diagnosis to resection (27.3 vs 35.5 days) compared with the pre-MDPC. Microscopically negative resections were similar between MDPC and pre-MDPC (85.9% vs 88.0%) despite advanced tumor size and stage. Conclusions The MDPC demonstrates a high resection rate. Compared with a pre-MDPC, MDPC provides shorter time to surgery and selects for advanced tumors. |
| Databáze: | OpenAIRE |
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