PHASE 1 SINGLE AND MULTIPLE ASCENDING DOSE STUDY OF CAT-2003, A NOVEL ACTIVATOR OF LIPOPROTEIN LIPASE, DEMONSTRATES REDUCTIONS IN POSTPRANDIAL TRIGLYCERIDES

Autor:	Lucasz Biernat, Douglas Logan, Michael Jirousek, Maria Cecilia Mancini, Richard L. Dunbar, Michael Curtis, Joanne M. Donovan
Rok vydání:	2014
Předmět:	Lipoprotein lipase medicine.medical_specialty business.industry Activator (genetics) digestive oral and skin physiology Hypertriglyceridemia food and beverages nutritional and metabolic diseases medicine.disease Eicosapentaenoic acid Sterol regulatory element-binding protein Postprandial Endocrinology Internal medicine medicine lipids (amino acids peptides and proteins) business Cardiology and Cardiovascular Medicine Niacin Conjugate
Zdroj:	Journal of the American College of Cardiology. 63(12)
ISSN:	0735-1097
DOI:	10.1016/s0735-1097(14)61450-9
Popis:	CAT-2003, an orally active small molecule, reduces fasting and postprandial triglycerides (TG) in rat models of hypertriglyceridemia (HTG) by inhibiting SREBP activation and decreasing inhibitors of lipoprotein lipase (LPL). CAT-2003, a conjugate of niacin and eicosapentaenoic acid, is inactive in
Databáze:	OpenAIRE
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