Effects of mechanical ventilation versus apnea on bi-ventricular pressure-volume loop recording
| Autor: | M DAM LYHNE, C SCHMIDT MORTENSEN, J VALENTIN HANSEN, S JUEL DRAGSBAEK, J NIELSEN-KUDSK, A ANDERSEN |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Physiology
Apnea Swine Heart Ventricles Stroke Volume General Medicine Articles Respiration Artificial/adverse effects Respiration Artificial Ventricular Function Left Stroke Volume/physiology Ventricular Function Right Ventricular Pressure Animals Apnea/diagnosis Ventricular Function Left/physiology |
| Zdroj: | Lyhne, M D, Mortensen, C S, Hansen, J V, Dragsbaek, S J, Nielsen-Kudsk, J E & Andersen, A 2022, ' Effects of mechanical ventilation versus apnea on bi-ventricular pressure-volume loop recording ', Physiological Research, vol. 71, no. 1, pp. 103-111 . https://doi.org/10.33549/physiolres.934787 Physiol Res |
| Popis: | Respiration changes intrathoracic pressure and lung volumes in a cyclic manner, which affect cardiac function. Invasive ventricular pressure-volume (PV) loops can be recorded during ongoing mechanical ventilation or in transient apnea. No consensus exists considering ventilatory mode during PV loop recording. The objective of this study was to investigate the magnitude of any systematic difference of bi-ventricular PV loop variables recorded during mechanical ventilation versus apnea. PV loops were recorded simultaneously from the right ventricle and left ventricle in a closed chest porcine model during mechanical ventilation and in transient apnea (n=72). Variables were compared by regression analyses. Mechanical ventilation versus apnea affected regression coefficients for important PV variables including right ventricular stroke volume (1.22, 95% CI [1.08-1.36], p=0.003), right ventricular ejection fraction (0.90, 95% CI [0.81-1.00], p=0.043) and right ventricular arterial elastance (0.61, 95%CI [0.55-0.68], p |
| Databáze: | OpenAIRE |
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